Inosine monophosphate synthase

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

PDB rendering based on 1p4r.
Identifiers
Symbols ATIC; AICAR; AICARFT; FLJ93545; IMPCHASE; PURH
External IDs OMIM601731 MGI1351352 HomoloGene2983 GeneCards: ATIC Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 471 108147
Ensembl ENSG00000138363 ENSMUSG00000026192
UniProt P31939 Q3UTQ3
RefSeq (mRNA) NM_004044.6 NM_026195.3
RefSeq (protein) NP_004035.2 NP_080471.2
Location (UCSC) Chr 2:
216.18 – 216.21 Mb
Chr 1:
71.6 – 71.63 Mb
PubMed search [1] [2]

Bifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene.[1][2][3]

ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide.

It has two functions:

References

  1. ^ Rayl EA, Moroson BA, Beardsley GP (Mar 1996). "The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping". J Biol Chem 271 (4): 2225–33. doi:10.1074/jbc.271.4.2225. PMID 8567683. 
  2. ^ Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (Nov 1997). "Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase". J Biochem 122 (2): 309–13. PMID 9378707. 
  3. ^ "Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=471. 

Further reading

External links